The Validation and Amplification of Random DNA Libraries with Modified Nucleobases for Click-SELEX
Aptamers are nucleic acid ligands which exhibit specific binding to a desired target.Oligonucleotides are limited in their ability to form hydrophobic interactions.The affinity of aptamers can be improved with the introduction of hydrophobic modifiers into the structure of nitrogenous bases.Click-SELEX is a powerful tool used for the development of